Seoul National University_ Lab. Y1 - 2020/2/11 Genomic heritabilities accounted for large fractions of narrow-sense heritabilities and RHM captured considerably more of the genomic heritability than GWAS. Linkage disequilibrium in A. thaliana, 214K SNPs and 1307 ... • GWAS is a powerful tool to understand the genetics of natural Would you like email updates of new search results? I want to perform genome-wide association mapping for plant disease-resistant genes. A GWAS of 6,382 high-quality DArTseq SNPs revealed 15 significant SNPs (P-value <10-3) on chromosomes 2D, 3B, 4D and 7B that were associated with KB resistance in individual years. Annu Rev Phytopathol 9(1):275–296, Foolad M (1999) Comparison of salt tolerance during seed germination and vegetative growth in tomato by QTL mapping. Higher SB severity, 82.3 ± 13.5 (mean ± SD), was recorded at the Banaras Hindu University (BHU) … The recessive mlo mutation in barley confers broad-spectrum resistance to biotrophic Erysiphe graminis f. sp. J Exp Bot 53(377):2089–2098, Causse M, Duffe P, Gomez M, Buret M, Damidaux R, Zamir D, Gur A, Chevalier C, Lemaire-Chamley M, Rothan C (2004) A genetic map of candidate genes and QTLs involved in tomato fruit size and composition. Nature 444(7117):323, Kang HM, Zaitlen NA, Wade CM, Kirby A, Heckerman D, Daly MJ, Eskin E (2008) Efficient control of population structure in model organism association mapping. Cui Z, Dong H, Zhang A, Ruan Y, Jiang S, He Y, Zhang Z. Sci Rep. 2020 May 18;10(1):8165. doi: 10.1038/s41598-020-65164-0. eCollection 2020. The GWAS study has identified a single locus of major effect contributing to beech bark disease resistance. Knowledge of this genetic locus contributing to resistance might be used in applied breeding, conservation and restoration programs.  |  QTL mapping for soybean (Glycine max L.) leaf chlorophyll-content traits in a genotyped RIL population by using RAD-seq based high-density linkage map. Out of 45,868 single nucleotide polymorphisms in a panel of 144 inbred lines, 18 novel candidate genes were associated with head smut resistance in maize. These candidate genes were classified into three groups, namely, resistance genes, disease response genes, and other genes with possible plant disease resistance functions. Front Genet. USA.gov. Several review papers and chapters on QTL mapping of disease resistance in maize have been published so far. Published by Elsevier Ireland Ltd. All rights reserved. Genome-wide association studies in tropical maize germplasm reveal novel and known genomic regions for resistance to Northern corn leaf blight. Phytopathology 96(3):221–225, Balint-Kurti PJ, Johal GS (2009) Maize disease resistance. AU - Vossen, Jack H. AU - van Eck, Herman J. PY - 2020/2/11. Proc Natl Acad Sci 108(17):6893–6898, Pratt RC, Gordon SG (2006) Breeding for resistance to maize foliar pathogens. Crown Copyright © 2012. This site needs JavaScript to work properly. 2016 Dec 7;6(12):3803-3815. doi: 10.1534/g3.116.034561. tritici (Pst), is a serious foliar disease of wheat. Li YX, Wu X, Jaqueth J, Zhang D, Cui D, Li C, Hu G, Dong H, Song YC, Shi YS, Wang T, Li B, Li Y. PLoS One. Bioinformatics 19(7):889–890, Castro A, Tacaliti M, Giménez D, Tocho E, Dobrovolskaya O, Vasicek A, Collado M, Snape J, Börner A (2008) Mapping quantitative trait loci for growth responses to exogenously applied stress induced hormones in wheat. Genetics 178(1):539–551, Zhang Z, Ersoz E, Lai C-Q, Todhunter RJ, Tiwari HK, Gore MA, Bradbury PJ, Yu J, Arnett DK, Ordovas JM (2010) Mixed linear model approach adapted for genome-wide association studies. These markers spanned a physical … The results will provide foundational information for further research into AMB-related genes. Nat Genet 43(2):163, Levings CS, Siedow JN (1992) Molecular basis of disease susceptibility in the Texas cytoplasm of maize. hordei, the causal pathogen of powdery mildew disease (54, 55). Coronary artery disease. We developed an automated image analysis to measure quantitative resistance to septoria tritici blotch (STB), a globally important wheat disease, enabling identification of small chromosome intervals containing plausible candidate genes for STB resistance. Genetics 176(1):645–657, Bent AF, Kunkel BN, Dahlbeck D, Brown KL, Schmidt R, Giraudat J, Leung J, Staskawicz BJ (1994) RPS2 of Arabidopsis thaliana: a leucine-rich repeat class of plant disease resistance genes. He added that while the risk variants found in this study may prove to be specific to African Americans, the genes and pathways uncovered by it are likely to play a role in AD more broadly. Spot blotch (SB) in barley is caused by the fungal pathogen Cochliobolus sativus and considered one of the major constraints to successful barley production. Nat Rev Genet 3(1):43, Flint-Garcia SA, Thuillet AC, Yu J, Pressoir G, Romero SM, Mitchell SE, Doebley J, Kresovich S, Goodman MM, Buckler ES (2005) Maize association population: a high-resolution platform for quantitative trait locus dissection. We developed an automated image analysis to measure quantitative resistance to septoria tritici blotch (STB), a globally important wheat disease, enabling identification of small chromosome intervals containing plausible candidate genes for STB resistance. Combined linkage and association mapping reveal QTL for host plant resistance to common rust (Puccinia sorghi) in tropical maize.  |  rs1799990, also known as Met129Val or M129V, is a SNP in the prion protein PRNP gene. The first group contains plant disease resistance R genes, such as GRMZM2G047152, which encode the protein with NBS domain. In many plants, disease resistance involves numerous genes and displays complex inheritance. Euphytica 202(1):1–11, Ullstrup A (1972) The impacts of the southern corn leaf blight epidemics of 1970-1971. 2020 Jul 15;11:742. doi: 10.3389/fgene.2020.00742. To identify genomic regions that are associated with blast resistance to the three isolates, we performed a GWAS using the disease scores and the 700 K SNP genotypes of the inoculated cultivars. The use of high-density genome-wide SNPs in GWAS not only allows the discovery of true candidate genes, but also enables a comprehensive view of the regulatory mechanism of the traits. Fusarium crown rot (FCR) is a severe and chronic disease in common wheat and is able to cause serious yield loss and health problems to human and livestock. As the European population accounts for just ~16% of the global population, there is a recognized need for more diverse GWAS dataset. Heritabilities for resistance to IPNV estimated using genomic information, were 0.53 and 0.82 for TD and BS, respectively. In this study, we sought to detect candidate genes that affect resistance to AMB using a GWAS with GBS SNP data. Identification of novel stripe rust resistance genes and cultivation of resistant cultivars are considered to be the most effective approaches to control this disease. After removing the SNPs with minor allele frequency (MAF) < 5% (4373 SNPs), Hardy–Weinberg equilibrium (HWE) < 0.00001 (6553 SNPs), and missing data >25% (1490 SNPs), 40,647 SNPs were used for the subsequent analyses. Trends Plant Sci 14(1):21–29, Poland JA, Bradbury PJ, Buckler ES, Nelson RJ (2011) Genome-wide nested association mapping of quantitative resistance to northern leaf blight in maize. However, association mapping like GWAS for QTLs underlying disease resistance to the BBD, has not been previously reported. GWAS for many diseases and disorders have not yet been performed and the large majority (79%) of participants in GWAS to-date are of European ancestry. The present study is the first to conduct a genome-wide association study (GWAS) of head smut resistance using the Illumina MaizeSNP50 array. Disease-resistant genetically modified animals C.B.A. G3 3(2):197–203, Thornsberry JM, Goodman MM, Doebley J, Kresovich S, Nielsen D, Buckler ES IV (2001) Dwarf8 polymorphisms associate with variation in flowering time. RESULTS: A germplasm collection of japonica rice was screened for F. fujikuroi resistance, allowing the identification of accessions with high-to-moderate levels of resistance to bakanae. However, a general review and compilation of the recent GWAS studies in the disease resistance of maize is limited. These results indicated that different types of disease resistance were present in the collection and that resistance was more prevalent in accessions from Lebanon and Syria than in those from Turkey. Head smut, caused by the fungus Sphacelotheca reiliana (Kühn) Clint, is a devastating global disease in maize, leading to severe quality and yield loss each year. This chapter compiles and integrates recent studies of the five major diseases of maize using GWAS. 0. Resistance is conditioned by multiple loci and is further complicated by the role of the environment in expression of the disease phenotype. Geng X, Sun G, Qu Y, Sarfraz Z, Jia Y, He S, Pan Z, Sun J, Iqbal MS, Wang Q, Qin H, Liu J, Liu H, Yang J, Ma Z, Xu D, Yang J, Zhang J, Li Z, Cai Z, Zhang X, Zhang X, Zhou G, Li L, Zhu H, Wang L, Pang B, Du X. Molecular Breeding Approaches for Disease Resistance in Sugarcane. tritici (Bgt). The first GWAS on HIV infection identified variants in the HLA-region to be most dominantly associated with viral load at set point [], which was successfully replicated in other cohorts [30–33, 35], using viral load control and disease progression as phenotypes.GWAS that used clinical disease progression as a phenotype, such as LTNP, survival time to AIDS-diagnosis and AIDS-related … •Disease resistance is NOT correlated with population structure late flowering early flowering. 88 ( 12 ): e0145549 including disease resistance R genes, such as linkage and! 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